2016 Publications
EFFECTS OF OXYTOCIN AND VASOPRESSIN ON PREFERENTIAL BRAIN RESPONSES TO NEGATIVE SOCIAL FEEDBACK
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Gozzi M, Dashow EM, Thurm A, Swedo SE, Zink CF. Neuropsychopharmacology, 2016 Nov 30.
GENETIC RISK MECHANISMS OF POSTTRAUMATICSTRESS DISORDER IN THE HUMAN BRAIN
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Bharadwaj, R. A., Jaffe, A. E., Chen, Q., Deep-Soboslay, A., Goldman, A. L., Mighdoll, M. I., Cotoia, J. A., Brandtjen, A. C., Shin, J., Hyde, T. M., Mattay, V. S., Weinberger, D. R. and Kleinman, J. E. (2016), Journal of Neuroscience Research. doi:10.1002/jnr.23957
USING INDUCED PLURIPOTENT STEM CELLS TO INVESTIGATE COMPLEX GENETIC PSYCHIATRIC DISORDERS
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Temme, S.J., Maher, B.J. & Christian, K.M. Curr Behav Neurosci Rep (2016) 3: 275. doi:10.1007/s40473-016-0100-7.
ILLUMINATING THE DARK ROAD FROM SCHIZOPHRENIA GENETIC ASSOCIATIONS TO DISEASE MECHANISMS.
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Li M, Weinberger DR. National Science Review, 12 October 2016.
ASSOCIATION OF FUNCTIONAL GENETIC VARIATION IN PP2A WITH PREFRONTAL WORKING MEMORY PROCESSING
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Rampino A, Di Carlo P, Fazio L, Ursini G, Pergola G, De Virgilio C, Gadaleta G, Giordano GM, Bertolino A, Blasi G. Behav Brain Res. 2016 Aug 31;316:125-130. doi: 10.1016/j.bbr.2016.08.054. [Epub ahead of print]
BRAIN CATECHOL-O-METHYLTRANSFERASE (COMT) INHIBITION BY TOLCAPONE COUNTERACTS RECOGNITION MEMORY DEFICITS IN NORMAL AND CHRONIC PHENCYCLIDINE-TREATED RATS AND IN COMT-VAL TRANSGENIC MICE
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Detrait ER, Carr GV, Weinberger DR, Lamberty Y. Behavioral Pharmacology, 2016.
RAIL-RNA: SCALABLE ANALYSIS OF RNA-SEQ SPLICING AND COVERAGE BIOINFORMATICS
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Nellore A, Collado-Torres L, Jaffe AE, Morton J, Alquicira-Hernández J, Leek JT, Langmead B. Bioinformatics. 2016 Sep 4. pii: btw575. [Epub ahead of print] DOI PMID.
LOSS OF PROMOTER IV-DRIVEN BDNF EXPRESSION IMPACTS OSCILLATORY ACTIVITY DURING SLEEP, SENSORY INFORMATION PROCESSING AND FEAR REGULATION
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Hill JL, Hardy NF, Jimenez DV, Maynard KR, Kardian AS, Pollock CJ, Schloesser, Martinowich K. Translational Psychiatry, 6(8):e873, 2016.
CRUCIAL ROLES OF ARP2/3 COMPLEX DURING MAMMALIAN CORTICOGENESIS
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Wang P, Chou F, Ramachandran S, Xia S, Chen H, Guo F, Suraneni P, Maher B, Li R. Development, 143(15), 2741-52, 2016.
CONSTANCE E. LIEBER, THEODORE R. STANLEY AND THE ENDURING IMPACT OF PHILANTHROPY ON PSYCHIATRIC RESEARCH
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Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O’Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK. Biol Psychiatry 80: 84-6, 2016.
FUNCTIONAL ROLE OF BDNF PRODUCTION FROM UNIQUE PROMOTERS IN AGGRESSION AND SEROTONIN SIGNALING
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Maynard KR, Hill JL, Calcaterra NE, Palko ME, Kardian A, Paredes D, Sukumar M, Adler BD, Jimenez DV, Schloesser RJ, Tessarollo L. Neuropsychopharmacology, 41(8), 1943-55, 2016.
DYNAMIC REGULATION OF RNA EDITING IN HUMAN BRAIN DEVELOPMENT AND DISEASE
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Taeyoung Hwang, Chul-Kee Park, Anthony K L Leung, Yuan Gao, Thomas M Hyde, Joel E Kleinman, Anandita Rajpurohit, Ran Tao, Joo Heon Shin & Daniel R Weinberger. Nature Neuroscience, 26 June 16.
SYNTHESIS AND OPTIMIZATION OF N-HETEROCYCLIC PYRIDINONES AS CATECHOL-O-METHYLTRANSFERASE (COMT) INHIBITORS
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Zhao Z, Harrison ST, Schubert JW, Sanders JM, Polsky-Fisher S, Zhang NR, McLoughlin D, Gibson CR, Robinson RG, Sachs NA, Kandebo M, Yao L, Smith SM, Hutson PH, Wolkenberg SE, Barrow JC. Bioorg Med Chem Lett. 26, 2952-6, 2016.
OBESITY AND AGE-RELATED ALTERATIONS IN THE GENE EXPRESSION OF ZINC-TRANSPORTER-PROTEINS IN THE HUMAN BRAIN
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Olesen RH, Hyde TM, Kleinman JE, Smidt K, Rungby J and Larsen A. Translational Psychiatry 6: e838, 2016.
DEVELOPMENT OF AN HTRF ASSAY FOR THE DETECTION AND CHARACTERIZATION OF INHIBITORS OF CATECHOL-O-METHYLTRANSFERASE
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Kimos M, Burton M, Urbain D, Caudron D, Martini M, Famelart M, Gillard M, Barrow J, Wood M. Journal of Biomolecular Screening, 21, 480-495, 2016.
ASSESSMENT OF GENETIC RISK FOR DISTRIBUTION OF TOTAL INTERSTITIAL WHITE MATTER NEURONS IN DORSOLATERAL PREFRONTAL CORTEX: ROLE IN SCHIZOPHRENIA
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McFadden WC, Jaffe AE, Ye T, Paltán-Ortiz JD, Hyde TM, Kleinman JE. Schizophrenia Research. May 27, 2016.
REGIONAL VARIATIONS IN BRAIN GYRIFICATION ARE ASSOCIATED WITH GENERAL COGNITIVE ABILITY IN HUMANS
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Gregory MD, Kippenhan JS, Dickinson D, Carrasco J, Mattay VS, Weinberger DR, Berman KF. Current Biology. May 23;26(10):1301-5, 2016.
ESTIMATING CHANGING CONTEXTS IN SCHIZOPHRENIA
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Kaplan CM, Saha DS, Molina JL, Hockeimer WD, Postell EM, Apud JA, Weinberger DR, Tan HY. Brain, p.aww095, 2016.
BRAIN-REGION-SPECIFIC ORGANOIDS USING MINI-BIOREACTORS FOR MODELING ZIKV EXPOSURE
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Qian X, et al. Cell, 165(5), pp.1238-1254, 2016.
A HUMAN-SPECIFIC AS3MT ISOFORM AND BORCS7 ARE MOLECULAR RISK FACTORS IN THE 10Q24.32 SCHIZOPHRENIA LOCUS
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Ming Li, Andrew E Jaffe, Richard E Straub, Ran Tao, Joo Heon Shin, Yanhong Wang, Qiang Chen, Chao Li, Yankai Jia, Kazutaka Ohi, Brady J Maher, Nicholas J Brandon, Alan Cross, Joshua G Chenoweth, Daniel J Hoeppner, Huijun Wei, Thomas M Hyde, Ronald McKay, Joel E Kleinman & Daniel R Weinberger. Nature Medicine, 09 May 16.
ASSOCIATION OF DNA METHYLATION DIFFERENCES WITH SCHIZOPHRENIA IN AN EPIGENOME-WIDE ASSOCIATION STUDY
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Montano C, et al. JAMA Psychiatry. May 1;73(5):506-14, 2016.
BEHAVIORAL, NEUROPHYSIOLOGICAL, AND SYNAPTIC IMPAIRMENT IN A TRANSGENIC NEUREGULIN1 (NRG1-IV) MURINE SCHIZOPHRENIA MODEL
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Papaleo F, Yang F, Paterson C, Palumbo S, Carr GV, Wang Y, Floyd K, Huang W, Thomas CJ, Chen, Weinberger DR, Law AJ. The Journal of Neuroscience, 36(17), pp.4859-4875, 2016.
METABOTROPIC GLUTAMATE RECEPTOR 3 (MGLU3; MGLUR3; GRM3) IN SCHIZOPHRENIA: ANTIBODY CHARACTERISATION AND A SEMI-QUANTITATIVE WESTERN BLOT STUDY
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García-Bea A, Walker MA, Hyde TM, Kleinman JE, Harrison PJ, Lane TA. Schizophrenia Research. Apr 27, 2016.
REDUCED KYNURENINE PATHWAY METABOLISM AND CYTOKINE EXPRESSION IN THE PREFRONTAL CORTEX OF DEPRESSED INDIVIDUALS
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Clark SM, Pocivavsek A, Nicholson JD, Notarangelo FM, Langenberg P, McMahon RP, Kleinman JE, Hyde TM, Stiller J, Postolache TT, Schwarcz R. Journal of Psychiatry and Neuroscience;1:8872147, 2016.
NEUROPROTECTIVE EFFECTS OF DOCOSAHEXAENOIC ACID ON HIPPOCAMPAL CELL DEATH AND LEARNING AND MEMORY IMPAIRMENTS IN A VALPROIC ACID-INDUCED RAT AUTISM MODEL
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Gao J, Wang X, Sun H, Cao Y, Liang S, Wang H, Wang Y, Yang F, Zhang F, Wu L. International Journal of Developmental Neuroscience. Apr; 49:67-78, 2016.
INOSITOL HEXAKISPHOSPHATE (IP6) GENERATED BY IP5K MEDIATES CULLIN-COP9 SIGNALOSOME INTERACTIONS AND CRL FUNCTION
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Scherer PC, Ding Y, Liu Z, Xu J, Mao H, Barrow JC, Wei N, Zheng N, Snyder SH, Rao F. Proc Natl Acad Sci. 113, 3503-8, 2016.
C1Q/TNF-RELATED PROTEIN9 (CTRP9) LEVELS ARE ASSOCIATED WITH OBESITY AND DECREASE FOLLOWING WEIGHT LOSS SURGERY
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Wolf RM, Steele KE, Peterson LA, Zeng X, Jaffe AE, Schweitzer MA, Magnuson TH, Wong GW. The Journal of Clinical Endocrinology & Metabolism. Mar 16:jc20161027, 2016.
SEEKING OPTIMAL REGION-OF-INTEREST (ROI) SINGLE-VALUE SUMMARY MEASURES FOR FMRI STUDIES IN IMAGING GENETICS
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Tong Y, Chen Q, Nichols TE, Rasetti R, Callicott JH, Berman KF, Weinberger DF, Mattay VS. PloS one, 11(3), e0151391, 2016.
PSYCHIATRIC RISK GENE TRANSCRIPTION FACTOR 4 REGULATES INTRINSIC EXCITABILITY OF PREFRONTAL NEURONS VIA REPRESSION OF SCN10A AND KCNQ1
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Matthew D. Rannals, Gregory R. Hamersky, Stephanie Cerceo Page, Morganne N. Campbell, Aaron Briley, Ryan A. Gallo, BaDoi N. Phan, Thomas M. Hyde, Joel E. Kleinman, Joo Heon Shin, Andrew E. Jaffe, Daniel R. Weinberger, Brady J. Maher. Neuron, 10 Mar 16.
STRONG COMPONENTS OF EPIGENETIC MEMORY IN CULTURED HUMAN FIBROBLASTS RELATED TO SITE OF ORIGIN AND DONOR AGE
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Ivanov NA, Tao R, Chenoweth JG, Brandtjen A, Mighdoll MI, Genova JD, Jaffe AE et al. (2016) Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age. PLoS Genet 12(2): e1005819.
BDNF RS6265 METHYLATION AND GENOTYPE INTERACT ON RISK FOR SCHIZOPHRENIA
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Ursini G, Cavalleri T, Fazio L, Angrisano T, Iacovelli L, Porcelli A, Maddalena G, Punzi G, Mancini M, Gelao B, Romano R. Epigenetics, 11(1), pp.11-23, 2016.
SCHIZOPHRENIA-ASSOCIATED HERG CHANNEL KV11.1-3.1 EXHIBITS A UNIQUE TRAFFICKING DEFICIT THAT IS RESCUED THROUGH PROTEASOME INHIBITION FOR HIGH THROUGHPUT SCREENING
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Calcaterra NE, Hoeppner DJ, Wei H, Jaffe AE, Maher BJ, Barrow JC. Scientific Reports, vol 6, 19976., 10.1038/srep19976, 2016.
KCNH2-3.1 EXPRESSION IMPAIRS COGNITION AND ALTERS NEURONAL FUNCTION IN A MODEL OF MOLECULAR PATHOLOGY ASSOCIATED WITH SCHIZOPHRENIA
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Carr GV, Chen J, Yang F, Ren M, Yuan P, Tian Q, Bebensee A, Zhang GY, Du J, Glineburg P, Xun R, Akhile O, Akuma D, Pickel J, Barrow JC, Papaleo F, Weinberger DR. Molecular Psychiatry, 2016.
GAD2 ALTERNATIVE TRANSCRIPTS IN THE HUMAN PREFRONTAL CORTEX, AND IN SCHIZOPHRENIA AND AFFECTIVE DISORDERS
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Davis KN, Tao R, Li C, Gao Y, Gondré-Lewis MC, Lipska BK, Hyde TM. PLoS ONE, 11(2), e0148558, 2016.
GENETIC INFLUENCES ON SCHIZOPHRENIA AND SUBCORTICAL BRAIN VOLUMES: LARGE-SCALE PROOF OF CONCEPT
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Franke B, et al. Schizophrenia Working Group of the Psychiatric Genomics Consortium; Psychosis Endophenotypes International Consortium; Wellcome Trust Case Control Consortium 2; Enigma Consortium, O’Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF. Nature Neuroscience. Feb 1, 2016.
OXYTOCIN AND SOCIAL ADAPTATION: INSIGHTS FROM NEUROIMAGING STUDIES OF HEALTHY AND CLINICAL POPULATIONS
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Ma Y, Shamay-Tsoory S, Han S, Zink CF. Trends in Cognitive Sciences, 20 (2):133-145, 2016.
IMPACT OF A CIS-ASSOCIATED GENE EXPRESSION SNP IN 20Q11.22 ON BIPOLAR DISORDER SUSCEPTIBILITY, HIPPOCAMPAL STRUCTURE AND COGNITIVE PERFORMANCE
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Li M, Luo X, Landen M, Bergen SE, Hultman CM, Li X, Zhang W, Yao Y, Zhang C, Liu J, Mattheisen M, Cichon S, Muhlesien TW, Degenhardt FA, Nothen MM, Schulze TG, Grigoroiu-Serbanescu M, Li H, Fuller CK, Chen C, Dong Q, Chen C, Jamain S, Leboyer M, Bellivier F, Etain B, Kahn J-P, Henry C, Preisig M, Kutalik Z, Castelao E, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, MooDS Consortium, The Swedish Bipolar Study Group, Rietschel M, Liu C, Kleinman JE, Hyde TM, Weinberger DR and Su B. British Journal of Psychiatry 208 128-137, 2016.
ACTIVITY-DEPENDENT SIGNALING: INFLUENCE ON PLASTICITY IN CIRCUITS CONTROLLING FEAR-RELATED BEHAVIOR
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Hill JL, Martinowich K. Current Opinion in Neurobiology. 36, pp. 59–65, 2016.
EARLY POSTNATAL GABAA RECEPTOR MODULATION REVERSES DEFICITS IN NEURONAL MATURATION IN A CONDITIONAL NEURODEVELOPMENTAL MOUSE MODEL OF DISC1
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Saito A, Taniguchi Y, Rannals MD, Merfeld EB, Ballinger MD, Koga M, Ohtani Y, Gurley DA, Sedlak TW, Cross A, Moss SJ. Molecular Psychiatry, 2016.
ADULT NEUROGENESIS AND COGNITIVE FUNCTION: RELEVANCE FOR DISORDERS ASSOCIATED WITH HUMAN AGING
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Martinowich K, Schloesser RJ. In Lazarov O, Tesco G, eds., Genes, Environment and Alzheimer’s Disease. San Diego: Academic Press, 52-78, 2016.
DIFFERENTIAL RESPONSE TO RISPERIDONE IN SCHIZOPHRENIA PATIENTS BY KCNH2GENOTYPE AND DRUG METABOLIZER STATUS
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Heide J, Zhang F, Bigos KL, Mann SA, Carr VJ, Weickert CS, Weinberger DR, Vandenberg JI. American Journal of Psychiatry, 173(1), 53-59. 10.1176/appi.ajp.2015.14050653, 2016.
MAPPING DNA METHYLATION ACROSS DEVELOPMENT, GENOTYPE AND SCHIZOPHRENIA IN THE HUMAN FRONTAL CORTEX
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Jaffe AE, Gao Y, Soboslay AD, Tao R, Hyde TM, Weinberger DR & Kleinman JE. Nature Neuroscience.