Zengyou-Ye-PhD

About

Zengyou Ye, Ph.D. is a Staff Scientist II and has been with the Lieber Institute since 2018. His research interests focus on revealing the cause and potential therapeutic strategies of cognitive disorders. Dr. Ye earned his Ph.D. degree in neurobiology from the University of Science and Technology of China. He first received his postdoctoral training in Prof. Hui-Lin Pan’s lab at the University of Texas MD Anderson Cancer Center. There, he found that hyperphosphorylation of NMDAR-NR2B by CK2 and hyperglycosylation of chloride transporter NKCC1 in the PVN both critically contribute to the etiology of hypertension. After this discovery, he joined Prof. David Linden’s Lab as a senior postdoc/research associate at Johns Hopkins University School of Medicine where he combined several cutting-edge technologies. These included electrophysiological recording and time-lapse in vivo 2-photon imaging, during which he found that the estrogen receptor GPER in the cortex is critical for cognitive recovery during estrogen replacement therapy.  He is currently exploring the defects in the neuron-oligodendrocyte network present in Pitt-Hopkins Syndrome or Schizophrenia via electrophysiological and MEA recording on iPSC-derived human neurons and mouse models.